Professor Khong, Pek-Lan

MBBS, M.D., FRCR(UK), FHKCR, FHKAM (Radiology)
Professor, Head of Department of Diagnostic Radiology, HKU
Honorary Consultant Radiologist, Department of Radiology, QueenMaryHospital, Hong Kong
HKU Scholar Hub : http://hub.hku.hk/cris/rp/rp00467
E-mail : plkhong@hku.hk

 

Research Interest

  1. General Paediatric Radiology, including perinatal and neonatal imaging.
  2. Paediatric Neuroradiology.
  3. Adult and Paediatric Oncology and Haematology, in particular, applications of PET-CT and advanced MR imaging modalities.
  4. Pre-clinical animal MR and PET imaging; translational research in animal models.
  5. Radiological Protection in Medicine
 

Selected Publications

 
1.  

Schlemmer HP, Bittencourt LK, D’Anastasi M, Domingues R, Khong PL, Lockhat Z, Muellner A, Reiser MF, Schilsky RL, Hricak H.  Global challenges for cancer imaging.  Journal of Global Oncology 2017 http://ascopubs.org/doi/full/10.1200/JGO.17.00036.  doi: 10.1200/JGO.17.00036

2.   Yuan H, Ai QY, Kwong DLW, Fong DYT, King AD, Lee VHF, Khong PL*.  Cervical nodal volume for prognostication and risk stratification of patients with nasopharyngeal carcinoma, and implications on the TNM-staging system.  Scientific Reports 2017;7(1):10387. Doi:10.1038/s41598-017-10423-w.
3.   Liu D, Chan ACY, Fong DYT, Lo CM, Khong PL*.  Evidence-based surveillance imaging schedule after liver transplantation for hepatocellular carcinoma recurrence.  Transplantation 2017 Jan;101(1):107-111. doi: 10.1097/TP.0000000000001513
4.   Yuan H, Tong DK, Vardhanabhuti V, Law SY, CHiu KW, Khong PL*.  PET/CT in the evaluation of treatment response to neoadjuvant chemoradiotherapy and prognostication in patients with locally advanced esophageal squamous cell carcinoma.  Nuclear Medicine Communication 2016;37(9):947-955. doi: 10.1097/MNM.0000000000000527.
5.   Liu D, Khong PL*, Gao Y, Mahmood U, Quinn B, St. Germain J, Xu GX, Dauer LT.  Radiation Dosimetry of Whole-Body Dual Tracer 18F-FDG and 11C-Acetate PET/CT for Hepatocellular Carcinoma. Journal of Nuclear Medicine 2016;57(6):907-912.
6.   Yuan H, Tong DK, Vardhanabhuti V, Khong PL*.  Factors that affect PERCIST-defined test-retest comparability: an exploration of feasibility in routine clinical practice.  Clinical Nuclear Medicine 2015;40(12):941-944.
7.   Liu D, Fong DY, Chan AC, Poon RT, Khong PL*.  Hepatocellular carcinoma: surveillance CT schedule after hepatectomy based on risk stratification.  Radiology 2015;274(1):133-140.
8.   Khong PL*, Huang B, Lee EY, Chan KS, Kwong YL. Midtreatment 18F-FDG PET/CT scan for early response assessment of SMILE therapy in natural killer/T-ccll lymphoma: a prospective study from a single center.  Journal of Nuclear Medicine 2014;55(6)911-916.
9.   Qiu D, Chan GC, Chu J, Chan Q, Ha SY, Moseley ME, Khong PL*. MR quantitative susceptibility imaging for the evaluation of iron loading in the brains of patients with B-thalassemia major.  American Journal of Neuroradiology 2014;35(6):1085-1090.
10.   Sanchez R, Khong PL, Ringertz H. Radiologic protection in pediatric radiology: ICRP recommendations. Pediatr Radiol. 2013 Aug; 43(8):920-1.
11.   Huang B, Wong CS, Whitcher B, Kwong DL, Lai V, Chan Q, Khong PL*. Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: comparison of semiquantitative and quantitative parameters and correlation with tumour stage. Eur Radiol. 2013 Jun; 23(6):1495-502. PubMed PMID: 23377545.
12.   Khong PL*, Ringertz H, Donoghue V, Frush D, Rehani M, Appelgate K, Sanchez R. ICRP publication 121: radiological protection in paediatric diagnostic and interventional radiology. Annals of the ICRP. 2013 Apr; 42(2):1-63.
13.   Khong PL*, Frush D, Ringertz H. Radiological protection in paediatric computed tomography. Annals of the ICRP. 2012 Oct-Dec; 41(3-4):170-8.
14.   Huang B, Chan T, Kwong DL, Chan WK, Khong PL*. Nasopharyngeal carcinoma: investigation of intratumoral heterogeneity with FDG PET/CT. AJR Am J Roentgenol. 2012 Jul; 199(1):169-74.
15.   Qiu D, Tan LH, Siok WT, Zhou K, Khong PL*. Lateralization of the arcuate fasciculus and its differential correlation with reading ability between young learners and experienced readers: a diffusion tensor tractography study in a Chinese cohort. Hum Brain Mapp. 2011 Dec; 32(12):2054-63.
16.   Chan WK, Kwong DL, Yeung DW, Huang B, Khong PL*. Prognostic impact of standardized uptake value of F-18 FDG PET/CT in nasopharyngeal carcinoma. Clin Nucl Med. 2011 Nov; 36(11):1007-11.
17.   Gu J, Chan T, Zhang J, Leung AY, Kwong YL, Khong PL*. Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma. AJR Am J Roentgenol. 2011 Sep; 197(3):W384-91.
18.   Chan WK, Au WY, Wong CY, Liang R, Leung AY, Kwong YL, Khong PL*. Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas. Clin Nucl Med. 2010 Aug; 35(8):571-5.
19.   Chan WK, Mak HK, Huang B, Yeung DW, Kwong DL, Khong PL*. Nasopharyngeal carcinoma: relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification. Nucl Med Commun. 2010 Mar; 31(3):206-10.
20.   Huang B, Law MW, Mak HK, Kwok SP, Khong PL*. Pediatric 64-MDCT coronary angiography with ECG-modulated tube current: radiation dose and cancer risk. AJR Am J Roentgenol. 2009 Aug; 193(2):539-44.
21.   Huang B, Law MW, Khong PL*. Whole-body PET/CT scanning: estimation of radiation dose and cancer risk. Radiology. 2009 Apr; 251(1):166-74.
22.   Wang S, Wu EX, Qiu D, Leung LH, Lau HF, Khong PL*. Longitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat model. Cancer Res. 2009 Feb; 69(3):1190-8.
23.   Khong PL*, Pang CB, Liang R, Kwong YL, Au WY. Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies. Ann Hematol. 2008 Aug; 87(8):613-21.
24.   Wang S, Wu EX, Tam CN, Lau HF, Cheung PT, Khong PL*. Characterization of white matter injury in a hypoxic-ischemic neonatal rat model by diffusion tensor MRI. Stroke. 2008 Aug; 39(8):2348-53.
25.   Qiu D, Tan LH, Zhou K, Khong PL*. Diffusion tensor imaging of normal white matter maturation from late childhood to young adulthood: voxel-wise evaluation of mean diffusivity, fractional anisotropy, radial and axial diffusivities, and correlation with reading development. Neuroimage. 2008 Jun; 41(2):223-32.
26.   Qiu D, Kwong DL, Chan GC, Leung LH, Khong PL*. Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? Int J Radiat Oncol Biol Phys. 2007 Nov; 69(3):846-51.
27.   Yung A, Poon G, Qiu DQ, Chu J, Lam B, Leung C, Goh W, Khong PL*. White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates. Pediatr Res. 2007 Jun; 61(6):732-6.
28.   Qiu D, Leung LH, Kwong DL, Chan GC, Khong PL*. Mapping radiation dose distribution on the fractional anisotropy map: applications in the assessment of treatment-induced white matter injury. Neuroimage. 2006 May; 31(1):109-15.
29.   Khong PL*, Leung LH, Fung AS, Fong DY, Qiu D, Kwong DL, Ooi GC, McAlanon G, Cao G, Chan GC. White matter anisotropy in post-treatment childhood cancer survivors: preliminary evidence of association with neurocognitive function. J Clin Oncol. 2006 Feb; 24(6):884-90.
30.   Wang Y, Cheung PT, Shen GX, Wu EX, Cao G, Bart I, Wong WH, Khong PL*. Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction. AJNR Am J Neuroradiol. 2006 Jan; 27(1):51-4.
31.   Khong PL*, Leung LH, Chan GC, Kwong DL, Wong WH, Cao G, Ooi GC. White matter anisotropy in childhood medulloblastoma survivors: association with neurotoxicity risk factors. Radiology. 2005 Aug; 236(2):647-52.
32.   Leung LH, Ooi GC, Kwong DL, Chan GC, Cao G, Khong PL*. White-matter diffusion anisotropy after chemo-irradiation: a statistical parametric mapping study and histogram analysis. Neuroimage. 2004 Jan; 21(1):261-8.
33.   Khong PL*, Chan GC, Lee SL, Au WY, Fong DY, Tsang KW, Ooi GC. Beta-thalassemia major: thin-section CT features and correlation with pulmonary function and iron overload. Radiology. 2003 Nov; 229(2):507-12.